Вальсальва

Efficacy and safety of aspirin for primary prevention of cardiovascular events: a meta-analysis and trial sequential analysis of randomized controlled trials.

Eur Heart J. 2018 Dec 17. doi: 10.1093/eurheartj/ehy813. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30561620

Еще одна цитата начала года:

Among adults without established cardiovascular disease, aspirin was not associated with a reduction in the incidence of all-cause mortality; however, it was associated with an increased incidence of major bleeding. The routine use of aspirin for primary prevention needs to be reconsidered.