Uric Acid and Cardiovascular Risk

[Pyankov Vasily]

Evidence regarding the relationship between high serum uric acid concentrations and hypertension and other cardiovascular risk factors is extensive. Furthermore, current data also suggest that hyperuricemia could increase the risk of developing renal and CV disease. Nevertheless, it is too early to make clinical recommendations in regard to the benefits of using xanthine oxidase inhibitor allopurinol or the novel febuxostat in patients with asymptomatic increased uric acid levels and high CV risk. Further studies are needed to assess the exact role of uric acid reduction in the progression of cardiorenal events. Antihypertensive drugs can, however, modify the development of gout events in hypertensive patients, with losartan and calcium channel blockers having the greatest lowering effect on blood pressure because of their uricosuric properties.

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