Separate genetic variants discovered for CAD and MI

[AOkhotin]

Стенокардия и инфаркт -- разные болезни, даже генетически.

Philadelphia, PA - Researchers have discovered two new genetic variants, one predisposing to the development of coronary atherosclerosis and the other predisposing to subsequent plaque rupture and acute MI [1].

In a paper published online in the Lancet on January 15, 2010, a team led by Dr Muredach Reilly (University of Pennsylvania, Philadelphia) concludes that "the relation to specific CAD phenotypes might modify how novel loci are applied in personalized risk assessment and used in the development of novel therapies for CAD."

Commenting for heartwire, Dr Eric Topol (Scripps Health, La Jolla, CA) described the latest findings as "interesting." He said: "A nice contribution here, by virtue of having angiographic data, was the dissection of the two phenotypes for CAD and MI (which have all too often been lumped together). Both of the new variants are common and carry a modest 20% to 30% increased risk [per risk allele] for either CAD or MI, respectively."

Topol noted that this work adds to the extensive genomewide association studies of CAD/MI, "but most of the heritability (>90%) for these conditions is left unexplained. . . . There is much more work to be done to get that sorted out." He added: "Also, unlike the previous SORT-1 story, the report does not provide any insights on the 'culprit' functional genomic variant implicated in either case, so that requires some extensive 'drill down,' as well."

http://www.theheart.org/article/1172979.do