Сначала клопи, теперь аспирин

[Sergey Chevychelov]

Сначала клопи, теперь аспирин
Patients with CAD treated with PPIs had a reduced response to
aspirin, as shown by increased residual platelet aggregation and
platelet activation, compared with patients with CAD not
taking PPIs. Concomitant use of aspirin and PPIs might leave
patients at an increased risk of thrombotic events. These
findings may affect the clinical practice of antithrombotic
treatment. In view of the widespread use of PPIs, a randomised
double-blind crossover study (PPI vs placebo + aspirin) is needed
to explore further the inhibitory effect of PPIs on aspirin.
http://kardter.narod.ru/he_96_5_368.pdf