Omega-3 Polyunsaturated Fatty Acids and Cardiovascular Diseases
Omega-3 polyunsaturated fatty acid therapy continues to show great promise in primary and, particularly in secondary prevention of cardiovascular (CV) diseases. The most compelling evidence for CV benefits of -3 PUFA comes from 4 controlled trials of nearly 40,000 participants randomized to receive eicosapentaenoic acid (EPA) with or without docosahexaenoic acid (DHA) in studies of patients in primary prevention, after myocardial infarction, and most recently, with heart failure (HF). We discuss the evidence from retrospective epidemiologic studies and from large randomized controlled trials showing the benefits of -3 PUFA, specifically EPA and DHA, in primary and secondary CV prevention and provide insight into potential mechanisms of these observed benefits. The target EPA + DHA consumption should be at least 500 mg/day for individuals without underlying overt CV disease and at least 800 to 1,000 mg/day for individuals with known coronary heart disease and HF. Further studies are needed to determine optimal dosing and the relative ratio of DHA and EPA -3 PUFA that provides maximal cardioprotection in those at risk of CV disease as well in the treatment of atherosclerotic, arrhythmic, and primary myocardial disorders.
J Am Coll Cardiol, 2009; 54:585-594
P.S. Коллеги а Вы назначаете своим пациентам Omega-3 polyunsaturated fatty acid ?
Omega-3 Fatty Acids and Cardiovascular Diseases
Модератор: Pyankov Vasily
-
- Сообщения: 5564
- Зарегистрирован: Пн ноя 24, 2008 12:59 am
- Откуда: Киров
-
- Сообщения: 1232
- Зарегистрирован: Сб апр 21, 2007 3:31 am
Omega-3 fatty acids в виде капсул не являются медицинскими препаратами.Они продаются в обычных супемаркетах и специализированных магазинах для биологически активных добавок.
http://www.umm.edu/altmed/articles/omega-3-000316.htm
http://www.umm.edu/altmed/articles/omega-3-000316.htm
-
- Сообщения: 5564
- Зарегистрирован: Пн ноя 24, 2008 12:59 am
- Откуда: Киров
В РФ зарегистрирован рецептурный препарат омега-3 ПНЖК "Омакор". Почти вся доказательная база по омега-3 ПНЖК получена в испытаниях с этим препаратом.Igor Bulatov писал(а):Omega-3 fatty acids в виде капсул не являются медицинскими препаратами.Они продаются в обычных супемаркетах и специализированных магазинах для биологически активных добавок.
http://www.umm.edu/altmed/articles/omega-3-000316.htm