One of the first large studies to look at the safety of different nonsteroidal anti-inflammatory drugs (NSAIDs) specifically in patients with heart disease has found that naproxen appears to have better cardiovascular safety than diclofenac, ibuprofen, and higher doses of rofecoxib (Vioxx, Merck) and celecoxib (Celebrex, Pfizer).
Results showed that cardiovascular safety was best for naproxen, which had a lower incidence rate ratio (IRR) for serious cardiovascular disease than non-NSAID users. In contrast, there was evidence that cardiovascular risk was increased for users of the other study NSAIDs.
Other results showed that individuals who took diclofenac had a 50% increased risk of MI, stroke, or death from any cause compared with naproxen users. The authors point out that diclofenac is widely used outside the US and has been the reference drug in several COX-2-inhibitor outcome trials, and this excess risk was present for low and moderate doses (<150> 200 mg/day) and rofecoxib (> 25 mg/day) had increased risk of serious coronary heart disease.
Circ Cardiovasc Qual Outcomes 2009; 2:155-163.
Naproxen Best NSAID for Heart-Disease Patients
Модератор: Pyankov Vasily
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Re: Naproxen Best NSAID for Heart-Disease Patients
ну ну... явная манипуляция.Pyankov Vasily писал(а): appears to have better cardiovascular safety than diclofenac, ibuprofen, and higher doses of rofecoxib (Vioxx, Merck) and celecoxib (Celebrex, Pfizer).
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А что, производитель напроксена занимается благотворительностью? ИМХО это попытка воспользоваться шумихой про повышения СС рисков селективных ингибиторов ЦОГ2 с маркетинговой целью.Igor Bulatov писал(а):Если бы это была манипуляция,то rofecoxib (Vioxx, Merck) and celecoxib (Celebrex, Pfizer) ( дорогие брэнд NSAIDs,продаются по рецептам) были бы лучше.В то время,как diclofenac и ibuprofen- дешевые дженерикс и продаются без рецептов.В чем смысл манипуляции или чьей-либо заинтересованности?