Propylthiouracil Linked With Risk for Serious Liver Damage, Death.
http://www.medscape.com/viewarticle/703 ... 05&src=ddd
Propylthiouracil Linked With Risk for Serious Liver Damage
Модератор: Pyankov Vasily
FDA Adds Boxed Warning to Propylthiouracil
http://www.fda.gov/Drugs/DrugSafety/Pos ... 209023.htm
http://www.medscape.com/viewarticle/720 ... ac=67436PZ
In summary, the FDA's recommendations for healthcare professionals are as follows:
Be aware that severe liver injury and acute liver failure, including fatal cases, have been reported in adult and pediatric patients taking propylthiouracil.
Propylthiouracil should be reserved for patients who cannot tolerate methimazole or for patients for whom radioactive iodine therapy or surgery is not appropriate treatment when initiating treatment.
Propylthiouracil may be the treatment of choice during and just before the first trimester of pregnancy, as fetal abnormalities have been observed with methimazole in early pregnancy.
Propylthiouracil is not recommended for use in pediatric patients except in rare instances in which other alternative treatments are not appropriate.
Encourage patients to read the medication guide when picking up their prescription for propylthiouracil.
Review the newly revised label for complete information on the use of propylthiouracil.
http://www.fda.gov/Drugs/DrugSafety/Pos ... 209023.htm
http://www.medscape.com/viewarticle/720 ... ac=67436PZ
In summary, the FDA's recommendations for healthcare professionals are as follows:
Be aware that severe liver injury and acute liver failure, including fatal cases, have been reported in adult and pediatric patients taking propylthiouracil.
Propylthiouracil should be reserved for patients who cannot tolerate methimazole or for patients for whom radioactive iodine therapy or surgery is not appropriate treatment when initiating treatment.
Propylthiouracil may be the treatment of choice during and just before the first trimester of pregnancy, as fetal abnormalities have been observed with methimazole in early pregnancy.
Propylthiouracil is not recommended for use in pediatric patients except in rare instances in which other alternative treatments are not appropriate.
Encourage patients to read the medication guide when picking up their prescription for propylthiouracil.
Review the newly revised label for complete information on the use of propylthiouracil.